I have a 110 and have the spare stowed away inside. I have installed a sub-floor on top of the wheel arches from the back of the rear seats to the door so the complete rear load space. The centre section between the arches in in three sections and hinged so that it folds up to the back of the seats. The wheel is secured to the floor under the hinged panels along with other bits and bobs I keep in the truck. I can move the wheel from lying flat on the floor to vertical behind the seats to vertical Infront of the seats depending on what space I need. I have only once had to move the wheel from lying flat and that was to transport an engineering lathe. I moved the wheel to Infront of the rear seats folded the panels up and used a forklift to put the lathe in. I needed the height from the original floor to get it in. If I have something in the load space and should need the wheel I can slide it out without folding the sub-floor panels up. Any drawbacks other than the initial work and cost no, not for me I think it was a good decision and really worked out well. Benefits, load removed from door, better rear view, more security for the wheel, the handling of the truck was greatly improved with moving the mass of the wheel more central in the vehicle.
I am currently installing alternative seats to the rear in which the seat base will hinge forward and the backs fold down to create a longer completely flat load area from the back of the front seats to the rear door. Big enough to lie down in an alternative doghouse when needed.
Tim