A Disco box uses the 1.2:1 ratio rather than the 1.4:1
This will up your gearing. If you are on standard 32" tall Defender tyres, then you will be over geared. A Disco on 29" tall tyres will pull approx the same mph per 1000rpm in top as a stock Defender does.
Swapping in the taller gearing in theory lowers your cruising rpms. But the downside is, it'll blunt performance/acceleration too. And you may find a stock Defender doesn't like pulling the lower rpm at high speed. Which means you may find you have to change down more often for hills and that you might end up with your foot welded to the floor to keep at a speed it used to manage fine.
So while in theory it could improve mpg, there is also a chance you'll drive it harder and end up using more fuel.
Example being, if you normally cruise at 60-65mph, then the 1.2:1 transfer box will easily allow this at lower rpm. So should be better on fuel, but will still blunt acceleration.
If you want to sit a 80mph, then you may find a stock diesel Defender won't like this, so you'll drive flat out all the time.